Arithmetic-Geometric-Harmonic (AGH) Method of Rough Estimation of Median Lethal Dose (Ld50) Using Up – and – Down Procedure

Arithmetic-Geometric-Harmonic (AGH) Method of Rough Estimation of Median Lethal Dose (Ld50) Using Up – and – Down Procedure

Earlier methods adopted for the estimation of median lethal dose (LD50) used many animals (40 – 100). But for the up – and – down procedure, 5 – 15 animals can be used, the number I still consider high. So this paper seeks to adopt arithmetic, geometric and harmonic (AGH) mean for rough estimation of median lethal dose (LD50) using up – and – down procedure by using 2 – 6 animals that may likel...

Median lethal dose (LD50) estimation of β-cyfluthrin in male and female Swiss albino mice

Present study was undertaken to determine the median lethal dose (LD50) of β-cyfluthrin (β-cyf), a synthetic (type II) pyrethroid pesticide in male and female Swiss albino mice. The calculation of LD 50 is an initial screening step in the assessment and evaluation of the toxic characteristic of a chemical substance. The selected single doses of β-cyfluthrin based on the pilot study were 200, 22...

Robust estimation of the median lethal dose.

Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions. For bioassays from a pharmaceutical company, these methods extend ...

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